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KMID : 0357920140480020126
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Korean Journal of Pathology
2014 Volume.48 No. 2 p.126 ~ p.132
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Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study
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Han Jae-Ho
Ko Young-Hyeh
Kang Yun-Kyung
Kim Wan-Seop
Kim Yoon-Jung
Kim In-Sun
Kim Hyun-Jung
Min Soo-Kee
Park Chan-Kum
Park Chan-Sik
Shin Bong-Kyung
Yang Woo-Ick
Oh Young-Ha
Lee Jong-Sil
Lee Ju-Hie
Lee Tae-Hui
Lee Hye-Kyung
Lee Ho-Jung
Jeon Yoon-Kyung
Cha Hee-Jeong
Choi Yoo-Duk
Kim Chul-Woo
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Abstract
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Background: Previously, cutaneous lymphomas were classified according to either the European Organization for the Research and Treatment of Cancer (EORTC) or the World Health Organization (WHO) classification paradigms. The aim of this study was to determine the relative frequency of Korean cutaneous lymphoma according to the new WHO-EORTC classification system.
Methods: A total of 517 patients were recruited during a recent 5 year-period (2006-2010) from 21 institutes and classified according to the WHO-EORTC criteria.
Results: The patients included 298 males and 219 females, and the mean age at diagnosis was 49 years. The lesions preferentially affected the trunk area (40.2%). The most frequent subtypes in order of decreasing prevalence were mycosis fungoides (22.2%), peripheral T-cell lymphoma (17.2%), CD30+ T-cell lymphoproliferative disorder (13.7%), and extranodal natural killer/T (NK/T) cell lymphoma, nasal type (12.0%). Diffuse large B-cell lymphoma accounted for 11.2% of cases, half of which were secondary cutaneous involvement; other types of B-cell lymphoma accounted for less than 1% of cases.
Conclusions: In comparison with data from Western countries, this study revealed relatively lower rates of mycosis fungoides and B-cell lymphoma in Korean patients, as well as higher rates of subcutaneous panniculitis-like T-cell lymphoma and NK/T cell lymphoma.
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KEYWORD
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Cutaneous lymphoma, World Health Organization, EORTC, Classification
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